PATHOGENIC PRIMING: VACCINE WORSENING THE DISEASE

 

Hundreds of children died in Philippines’ botched Vaccine launch

“(The) unique safety problem of coronavirus vaccines was discovered 50 years ago while developing the Respiratory Syncytial Virus (RSV) vaccine…… (This) ‘paradoxical immune enhancement phenomenon’ means vaccinated people may still develop the disease, get sicker and die.”

 Dr. Peter Hotez, (Strong Vaccine Proponent ) in a testimony before  the US Congress March 5,  2020. 

It is well-established but hardly mentioned to the general public, that people who receive ANY of the various vaccines being produced against the SARS COV-2 virus stand a definite risk of becoming much more susceptible not only to COVID-19 disease, but also to other clinical diseases caused by other strains in the coronavirus family.  This situation, where vaccination leads to disease enhancement rather than reduction, is known as Pathogenic Priming.  It arises principally from autoimmune issues and is the singular reason no vaccine has been approved to date for any coronavirus since the two decades when the efforts began. In the current developments, proposals have been made that could presumably address the problem; but under the cover of a supposed global pandemic that is threatening to decimate the entire world’s population, the required animal trials to check the efficacy of such ideas have been skipped! And most people have no clue as to the extent of risks they are being asked to bear.

Autoimmune problems refer to the situation where the body’s immune system begins to confuse its own proteins for foreign dangerous proteins it had been taught (here, by the vaccine) to vehemently attack and destroy. This occurs because several proteins in the viral particles could be similar to those found in humans.  In COVID-19, every protein in the SARS-CoV-2 has at least one epitope (parts of viral proteins) that matches human proteins somewhere in the human body. About one-third of the epitopes in SARS-CoV-2 virus  match proteins in the human immune system.

In a nutshell, in Pathogenic Priming, recipients of a vaccine for a coronavirus like SARS, MERS, (also applicable for dengue and  RSV) develop appreciable antibodies in response to the vaccination, and on the basis of this, some impressive efficacy figure is ascribed to the vaccine.  There also is not much adverse health effect apparent at this juncture, so the vaccine gets a clean safety profile as well. 

However the problem arises when the vaccine recipients are exposed to the “wild virus” (the real virus from a natural infection rather than one packaged in a vaccine dose), or an entirely new strain at a future date.  Rather than prove protective, the prior vaccination turns out to render those vaccinated far more susceptible than they would have been without the vaccination!

Hints of Pathogenic priming had been first observed during the development of the failed RSV vaccine tests in the 1960s. The vaccines not only failed to prevent infection (as is also the case with current COVID-19 vaccines); 80% of the children infected required hospitalization, and two children who got exposed to the RSV died.  Immunopathological lung reactions were also observed in infants and in animals when they were challenged naturally (infants) and artificially (animals) after they had received RSV Vaccine.

 

The problem became quite apparent in the early 2000’s in the quest for vaccines against coronaviruses  like SARS-COV-1 and MERS.  In the animal trials, the four most promising vaccines were administered to animals including ferrets, non-human primates, and mice. All the animals promptly developed a robust antibody response to coronavirus, and the experiments were adjudged successful. However, when the vaccinated animals were later exposed to the wild virus, the results were horrifying. Vaccinated animals suffered hyper-immune responses including extreme inflammation throughout their bodies, especially in their lungs.  They all died and the vaccine efforts were halted. 

 

Dr Anthony Fauci however proceeded with his dengue vaccine in 2014, despite clear evidences of pathogenic priming, as people who got the vaccine became “incredibly sick” when they later got exposed to the wild virus.  The vaccine was subsequently administered to 100,000 children in the Philippines, and again, all appeared to be well until the children finally encountered wild dengue.  They became “horrendously sick” and 600 of them died. Today the Philippine government is criminally prosecuting the Philippine health officials who waved the vaccine through.

Another untoward autoimmune-related condition associated with coronavirus vaccines is antibody-dependent enhancement (ADE), also known in related forms as Paradoxical Immune Enhancement, Cytokine Storm, and Virus Interference, among others.  In ADE, vaccines generate in addition to the desired neutralizing antibodies that protect against the target virus, other idiopathic antibodies which facilitate the entrance and rapid replication within the cell, the very target virus the vaccine was meant to protect against!  This is the exact opposite of protecting someone from an infection; and (especially if the binding antibodies persist longer than the neutralising ones) it can lead to the vaccinated person becoming much more susceptible to the disease than he would have been had he remained unvaccinated. ADE has been demonstrated in studies on SARS CoV in humans, ferrets (liver damage) and non-human primates (acute lung damage), among a much larger body of literature.  It was the reason for the failure of the 2012 attempt to produce a SARS coronavirus vaccine. 

In the ongoing developments with SARS Cov 2, sober voices calling for caution are being shunned into silence.  Nevertheless, concerns are being raised “whether vaccine recipients will develop more severe disease if they are exposed to or infected with SARS-CoV after neutralizing antibody titers decline” and “ whether recipients of a SARSCoV vaccine would be at risk of developing pulmonary immunopathology following infection with an unrelated human coronavirus e.g. 229E, OC43, HKU1 or NL63 that usually causes mild, self- limited disease.”

Writing to a regulatory body in the US on 6^th December, 2020, James Lyons-Weiler, warned: “Since no animal studies were conducted on older animals, we have no idea of the COVID19 vaccines being considered will cause pathogenic priming leading to disease enhancement in the liver, pancreas, spleen, brain, intestines, and central nervous system.  Unqualified recommendations of COVID19 vaccines could lead to a public health crisis due to disease enhancement that makes 2020 look like a walk in the park.”

Evidences currently amassing suggest that “Pathogenic Priming” is already “Likely Contributing to Serious and Critical Illness and Mortality in COVID-19 via Autoimmunity.”  In the United States, by the end of December 2020, the Vaccine Adverse Effects Reporting System (which is known to capture only about 1% of adverse health effects) already is bursting with reports of adverse events, ranging from life-threatening anaphylaxis and emergency room visits to brain inflammation and death.  The number of United States deaths on the VAERS (13 deaths) does not include the 24 deaths reported (out of a total 193 residents vaccinated) in a single nursing home in New York. As at 18^th January, Norway is already investigating 33 deaths associated with receipt of COVID-19 vaccine, while Germany is investigating 10 deaths!  While the causes of death have been established in some cases, e.g Dr Gregory Michael (died of acute idiopathic thrombocytopenic purpura - ITP), in other cases, no clear reasons has been adduced for the deaths. According to James Lyons-Weler and Robert F. Kennedy, it is highly probable that we are already seeing cases of pathogenic priming!

A recent review of ADE noted that the condition is expected to be exacerbated in people who already have some existing autoimmune disease at the time of their being vaccinated. Such category of people were actually excluded in the clinical trials of the vaccines; but it has been pointed out that most people with autoimmune diseases are probably not aware of their condition!  In the USA, estimates of this sub-population range  from 14.7 million to 23.5 million.  Thanks to the excellent review by Adelowo and Bello (2014), it is now understood that contrary to long-held views, systemic autoimmune diseases are “not so rare” in Nigerians afterall, and that the challenge lies more with getting a correct diagnosis.  Even in the advanced western countries, accurate diagnosis of some autoimmune problems such as Lupus could take well over a year, and would entail shuttling between various specialist medical practitioners! For instance, the symptoms for Lupus could include joint pains, weakness, chest pains, fever, weight loss, skin rash, swollen nodes and ulcers - all which could be adduced to other causes, rather than autoimmune dysfunctionality.

Which brings us to the issue of Informed Consent.  The peer reviewed article by Timothy Cardozo and Ronald Veazey wondered how people could be expected to give informed consent to receiving the COVID vaccine, when most of them have never heard of pathogenic priming and ADE to begin with! Furthermore, only few understand that this first-of-its-kind vaccine for a coronavirus has been licensed for public use, only in an “experimental capacity” Marshalling their points to call for a separate Informed Consent Form to explain these germane issues concerning COVID-19 vaccines to the general public before administration of vaccines, Cardozo and Veazey wrote:

“COVID-19 vaccines designed to elicit neutralising antibodies may sensitise vaccine recipients to more severe disease than if they were not vaccinated. Vaccines for SARS, MERS and RSV have never been approved, and the data generated in the development and testing of these vaccines suggest a serious mechanistic concern: that vaccines designed empirically using the traditional approach (consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies), be they composed of protein, viral vector, DNA or RNA and irrespective of delivery method, may worsen COVID-19 disease via antibody-dependent enhancement (ADE). This risk is sufficiently obscured in clinical trial protocols and consent forms for ongoing COVID-19 vaccine trials that adequate patient comprehension of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials.”

It is unfortunate that rather than step up efforts to inform the general public about the actual risks associated with COVID-19 vaccines, and promote studies that can help identify the sub-populations most vulnerable and how the risks may be mitigated, our public health institutions in Nigeria, are only frantically devising efforts to convince or coerce the masses to receiving the vaccine, while parroting safety claims spurned out by the profit-minded foreign vaccine producers and marketers!

Seeing that the facts of Pathogenic Priming and Antibody-Dependent Enhancement are freely available in the public domain, however, it would amount to outright CRIMINALITY for those currently in charge of our public health institutions to ignore these realities and continue with the planned massive indiscriminate administration of imported purely EXPERIMENTAL vaccines to people who have not been adequately informed of the basic and well-established risks involved.  Such public officers involved should understand that they would be called to account for their criminal action, not only in the hereafter, but even here on earth, before some appropriate Tribunal in due course.

On a closing note, Pathogenic Priming and Vaccine-elicited Enhancement of diseases will explain the projection of some seemingly omniscient forecasters, who have been predicting the coming of a more deadly variant of COVID for the second quarter of 2021, by which time hundreds of millions of vaccine doses are expected to have been administered.  Whereas, it has been globally acknowledged that Nigerians (and Africans in general) have been much less vulnerable to COVID than the rest of the world, the vaccine could possibly change this pleasant narrative, rendering our people more vulnerable to the same virus they had previously successfully resisted.  The new development, God forbid it happens, could then conveniently be interpreted as the arrival of a new more deadly variant, presumably calling for new vaccines and plunging the continent further into the bottomless abyss.

All thinking literate Nigerians are duty-bound to resist these efforts to administer deadly medical products into the bodies of our unsuspecting fellow compatriots. And for anyone who after receiving all this information still considers refusing the vaccine too expensive a proposition (perhaps due to some socio-economic carrots attached), we would advise them to take time to read this indepth PremiumTimes report on the presentation of autoimmune diseases in Nigeria. To get ready for what might be coming their way!